OKCAM: an ontology-based, human-centered knowledgebase for cell adhesion molecules.

ABSTRACT: 'Cell adhesion molecules' (CAMs) are essential elements of cell/cell communication that are important for proper development and plasticity of a variety of organs and tissues. In the brain, appropriate assembly and tuning of neuronal connections is likely to require appropriate function of many cell adhesion processes. Genetic studies have linked and/or associated CAM variants with psychiatric, neurologic, neoplastic, immunologic and developmental phenotypes. However, despite increasing recognition of their functional and pathological significance, no systematic study has enumerated CAMs or documented their global features. We now report compilation of 496 human CAM genes in six gene families based on manual curation of protein domain structures, Gene Ontology annotations, and 1487 NCBI En

SUBMITTER: Li CY 

PROVIDER: S-EPMC2686464 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature