C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

ABSTRACT:

Background

Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ambulatory populations. However, the influence of CRP gene variants on CRP levels during inflammatory states, such as surgery, is largely unexplored. We describe the association between candidate CRP gene variants and postoperative plasma CRP levels in patients undergoing primary, elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB).

Methods

Using a multicenter candidate gene association study design, we examined the association between seventeen candidate CRP single nucleotide polymorphisms (SNPs) and inferred haplotypes, and

SUBMITTER: Perry TE 

PROVIDER: S-EPMC2686694 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature