Identification of genes differentially expressed in dorsal and ventral chick midbrain during early development.

ABSTRACT:

Background

During the development of the central nervous system (CNS), patterning processes along the dorsoventral (DV) axis of the neural tube generate different neuronal subtypes. As development progresses these neurons are arranged into functional units with varying cytoarchitecture, such as laminae or nuclei for efficient relaying of information. Early in development ventral and dorsal regions are similar in size and structure. Different proliferation rates and cell migration patterns are likely to result in the formation of laminae or nuclei, eventually. However, the underlying molecular mechanisms that establish these different structural arrangements are not well understood.We undertook a differential display polymerase chain reaction (DD-PCR) screen to identify genes with d

SUBMITTER: Chittka A 

PROVIDER: S-EPMC2686707 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature