Correlation of expression profiles between microRNAs and mRNA targets using NCI-60 data.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNAs affecting the expression of target genes via translational repression or mRNA degradation mechanisms. With the increasing availability of mRNA and miRNA expression data, it might be possible to assess functional targets using the fact that a miRNA might down-regulate its target mRNAs. In this work we computed the correlation of expression profiles between miRNAs and target mRNAs using the NCI-60 expression data. The aim is to investigate whether the correlations between miRNA and mRNA expression profiles, either positive or negative, can be used to assist the identification of functional miRNA-mRNA relationships.

Results

Predicted miRNA-mRNA interactions were taken from TargetScan 4.1 and miRBase release 5. Pearson corr

SUBMITTER: Wang YP 

PROVIDER: S-EPMC2686738 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature