Diversity of Ehrlichia ruminantium major antigenic protein 1-2 in field isolates and infected sheep.

ABSTRACT: Proteins expressed from the map1 multigene family of Ehrlichia ruminantium are strongly recognized by immune T and B cells from infected animals or from animals that were infected and have recovered from heartwater disease (although still remaining infected carriers). Analogous multigene clusters also encode the immunodominant outer membrane proteins (OMPs) in other ehrlichial species. Recombinant protein analogs of the expressed genes and DNA vaccines based on the multigene clusters have been shown to induce protective immunity, although this was less effective in heterologous challenge situations, where the challenge strain major antigenic protein 1 (MAP1) sequence differed from the vaccine strain MAP1. Recent data for several ehrlichial species show differential expression of the OMPs i

SUBMITTER: Barbet AF 

PROVIDER: S-EPMC2687337 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature