Transcriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures.

ABSTRACT:

Background

Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial survival or death at supra-physiological temperatures. This study analyzed diverse facets of S. aureus heat-shock adjustment by recording global transcriptomic and metabolic responses of bacterial cultures shifted for 10 min from 37 degrees C to a sub-lethal (43 degrees C) or eventually lethal (48 degrees C) temperature. A relevant metabolic model of the combined action of specific stress response mechanisms with more general, energy-regulating metabolic pathways in heat-shocked S. aureus is presented.

Results

While S. aureus cultures shifted to 43 degrees

SUBMITTER: Fleury B 

PROVIDER: S-EPMC2687450 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature