CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines.

ABSTRACT:

Introduction

Metastasis is a complex process involving loss of adhesion, migration, invasion and proliferation of cancer cells. Cell adhesion molecules play a pivotal role in this phenomenon by regulating cell-cell and cell-matrix interactions. CD146 (MCAM) is associated with an advanced tumor stage in melanoma, prostate cancer and ovarian cancer. Studies of CD146 expression and function in breast cancer remain scarce except for a report concluding that CD146 could act as a tumor suppressor in breast carcinogenesis.

Methods

To resolve these apparent discrepancies in the role of CD146 in tumor cells, we looked at the association of CD146 expression with histoclinical features in human primary breast cancers using DNA and tissue microarrays. By flow cytometry, we characterized

SUBMITTER: Zabouo G 

PROVIDER: S-EPMC2687703 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature