Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy.

ABSTRACT:

Aims/hypothesis

Diabetic nephropathy, characterised by persistent proteinuria, hypertension and progressive kidney failure, affects a subset of susceptible individuals with diabetes. It is also a leading cause of end-stage renal disease (ESRD). Non-synonymous (ns) single nucleotide polymorphisms (SNPs) have been reported to contribute to genetic susceptibility in both monogenic disorders and common complex diseases. The objective of this study was to investigate whether nsSNPs are involved in susceptibility to diabetic nephropathy using a case-control design.

Methods

White type 1 diabetic patients with (cases) and without (controls) nephropathy from eight centres in the UK and Ireland were genotyped for a selected subset of nsSNPs using Illumina's GoldenGate BeadArray assay.

SUBMITTER: Savage DA 

PROVIDER: S-EPMC2687720 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature