Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells.

ABSTRACT:

Background

Despite the prevalence and biological relevance of both signaling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signaling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis using splicing-sensitive microarrays of changes in alternative splicing induced by activation of two distinct signaling pathways, insulin and wingless, in Drosophila cells in culture.

Results

Alternative splicing changes induced by insulin affect more than 150 genes and more than 50 genes are regulated by wingless activation. About 40% of the genes showing changes in alternative splicing also show regulation of mRNA levels, suggesting distinct but also significantly overlapping programs of transcriptional and post-tr

SUBMITTER: Hartmann B 

PROVIDER: S-EPMC2687788 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature