Comparative analysis of processed ribosomal protein pseudogenes in four mammalian genomes.

ABSTRACT:

Background

The availability of genome sequences of numerous organisms allows comparative study of pseudogenes in syntenic regions. Conservation of pseudogenes suggests that they might have a functional role in some instances.

Results

We report the first large-scale comparative analysis of ribosomal protein pseudogenes in four mammalian genomes (human, chimpanzee, mouse and rat). To this end, we have assigned these pseudogenes in the four organisms using an automated pipeline and make the results available online. Each organism has a large number of ribosomal protein pseudogenes (approximately 1,400 to 2,800). The majority of them are processed (generated by retrotransposition). However, we do not see a correlation between the number of pseudogenes associated with a ribosomal

SUBMITTER: Balasubramanian S 

PROVIDER: S-EPMC2687790 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature