STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.

ABSTRACT:

Background

Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively activated IFN/STAT1 pathway suggest an association with an aggressive tumor phenotype. We hypothesized that tumor clones that constitutively overexpress this pathway are preferentially selected by the host microenvironment due to a resistance to STAT1-dependent cytotoxicity and demonstrate increased metastatic ability combined with increased resistance to genotoxic stress.

Methodology/principal findings

Here we report that clones of B16F1 tumors grown in the lungs of syngeneic C57BL/6 mice demonstrate variable transcriptional levels of IFN/STAT1 pathway expression. Tumor cells that constitutively overexpres

SUBMITTER: Khodarev NN 

PROVIDER: S-EPMC2688034 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature