Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug.

ABSTRACT:

Introduction

Glucocorticoids are a mainstay of anti-inflammatory therapy, but significant adverse effects ultimately limit their utility. Previous efforts to design glucocorticoid structures with an increased therapeutic window have focused on dissociating anti-inflammatory transcriptional repression from adverse effects primarily driven by transcriptional activation. An alternative to this medicinal chemistry approach is a systems biology based strategy that seeks to amplify selectively the anti-inflammatory activity of very low dose glucocorticoid in immune cells without modulating alternative cellular networks that mediate glucocorticoid toxicity.

Methods

The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo model

SUBMITTER: Zimmermann GR 

PROVIDER: S-EPMC2688244 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature