Asymmetric relationships between proteins shape genome evolution.

ABSTRACT:

Background

The relationships between proteins are often asymmetric: one protein (A) depends for its function on another protein (B), but the second protein does not depend on the first. In metabolic networks there are multiple pathways that converge into one central pathway. The enzymes in the converging pathways depend on the enzymes in the central pathway, but the enzymes in the latter do not depend on any specific enzyme in the converging pathways. Asymmetric relations are analogous to the "if->then" logical relation where A implies B, but B does not imply A (A->B).

Results

We show that the majority of relationships between enzymes in metabolic flux models of metabolism in Escherichia coli and Saccharomyces cerevisiae are asymmetric. We show furthermore that these asymmet

SUBMITTER: Notebaart RA 

PROVIDER: S-EPMC2688278 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature