Exploiting lipid raft transport with membrane targeted nanoparticles: a strategy for cytosolic drug delivery.

ABSTRACT: The ability to specifically deliver therapeutic agents to selected cell types while minimizing systemic toxicity is a principal goal of nanoparticle-based drug delivery approaches. Numerous cellular portals exist for cargo uptake and transport, but after targeting, intact nanoparticles typically are internalized via endocytosis prior to drug release. However, in this work, we show that certain classes of nanoparticles, namely lipid-coated liquid perfluorocarbon emulsions, undergo unique interactions with cells to deliver lipophilic substances to target cells without the need for entire nanoparticle internalization. To define the delivery mechanisms, fluorescently-labeled nanoparticles complexed with alphav beta 3-integrin targeting ligands were incubated with alphav beta 3-integrin express

SUBMITTER: Partlow KC 

PROVIDER: S-EPMC2688337 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature