Genes regulated by caloric restriction have unique roles within transcriptional networks.

ABSTRACT: Caloric restriction (CR) has received much interest as an intervention that delays age-related disease and increases lifespan. Whole-genome microarrays have been used to identify specific genes underlying these effects, and in mice, this has led to the identification of genes with expression responses to CR that are shared across multiple tissue types. Such CR-regulated genes represent strong candidates for future investigation, but have been understood only as a list, without regard to their broader role within transcriptional networks. In this study, co-expression and network properties of CR-regulated genes were investigated using data generated by more than 600 Affymetrix microarrays. This analysis identified groups of co-expressed genes and regulatory factors associated with the mamma

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC2688445 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature