Massive comparative genomic analysis reveals convergent evolution of specialized bacteria.

ABSTRACT:

Background

Genome size and gene content in bacteria are associated with their lifestyles. Obligate intracellular bacteria (i.e., mutualists and parasites) have small genomes that derived from larger free-living bacterial ancestors; however, the different steps of bacterial specialization from free-living to intracellular lifestyle have not been studied comprehensively. The growing number of available sequenced genomes makes it possible to perform a statistical comparative analysis of 317 genomes from bacteria with different lifestyles.

Results

Compared to free-living bacteria, host-dependent bacteria exhibit fewer rRNA genes, more split rRNA operons and fewer transcriptional regulators, linked to slower growth rates. We found a function-dependent and non-random loss of the s

SUBMITTER: Merhej V 

PROVIDER: S-EPMC2688493 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature