Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNA.

ABSTRACT:

Background

Zeta-associated protein 70 (ZAP70) is a widely recognized prognostic factor in chronic lymphocytic leukemia, but mechanisms by which its higher expression leads to a poor outcome must still be fully explained.

Design and methods

In an attempt to unveil unfavorable cellular properties linked to high ZAP70 expression, we used gene expression profiling to identify genes associated with disparities in B cells from chronic lymphocytic leukemia patients expressing high versus low ZAP70 mRNA, measured by quantitative real-time PCR. Two groups of 7 patients were compared, selected on the basis of either high or low ZAP70 mRNA expression.

Results

Twenty-seven genes were differentially expressed with an FDR<10%, and several genes were significant predictors of treatm

SUBMITTER: Stamatopoulos B 

PROVIDER: S-EPMC2688570 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature