Radial chromatin positioning is shaped by local gene density, not by gene expression.

ABSTRACT: G- and R-bands of metaphase chromosomes are characterized by profound differences in gene density, CG content, replication timing, and chromatin compaction. The preferential localization of gene-dense, transcriptionally active, and early replicating chromatin in the nuclear interior and of gene-poor, later replicating chromatin at the nuclear envelope has been demonstrated to be evolutionary-conserved in various cell types. Yet, the impact of different local chromatin features on the radial nuclear arrangement of chromatin is still not well understood. In particular, it is not known whether radial chromatin positioning is preferentially shaped by local gene density per se or by other related parameters such as replication timing or transcriptional activity. The interdependence of these dis

SUBMITTER: Kupper K 

PROVIDER: S-EPMC2688818 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature