Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses.

ABSTRACT: RNA interference (RNAi) for cancer treatment relies on the ability to directly kill cancer cells via down-regulation of target genes, but issues of delivery and efficacy have limited clinical adoption. Furthermore, current studies using immune-deficient animal models disregard potential interactions with the adaptive immune system. It has previously been observed that certain viral antigens appear to be more rapidly presented to the immune system than normal proteins due to the production of defective ribosomal products by the virus. Given that RNAi could potentially result in the generation of truncated mRNAs, we wondered whether a similar mechanism of immune presentation of a target gene was possible. Here we show that RNAi-cleaved mRNAs can be translated into incomplete protein, and if

SUBMITTER: Gu W 

PROVIDER: S-EPMC2688843 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature