Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii.

ABSTRACT:

Background

Toxoplasma gondii is a member of the phylum Apicomplexa, which consists entirely of parasitic organisms that cause several diseases of veterinary and human importance. Fundamental mechanisms of gene regulation in this group of protistan parasites remain largely uncharacterized. Owing to their medical and veterinary importance, genome sequences are available for several apicomplexan parasites. Their genome sequences reveal an apparent paucity of known transcription factors and the absence of canonical cis-regulatory elements. We have approached the question of gene regulation from a sequence perspective by mining the genomic sequence data to identify putative cis-regulatory elements using a de novo approach.

Results

We have identified putative cis-regulatory elemen

SUBMITTER: Mullapudi N 

PROVIDER: S-EPMC2688925 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature