T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers.

ABSTRACT:

Introduction

Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated with a more favorable outcome. However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor.

Methods

Affymetrix HG-U133A microarray data of 1,781 primary breast cancer samples from 12 datasets were included. The correlation of immune system-related metagenes with different immune cells, clinical parameters, and survival was analyzed.

Results

A large cluster of nearly 600 genes with functions in immune cells was consistently obtained in all datasets. Seven robust metagenes

SUBMITTER: Rody A 

PROVIDER: S-EPMC2688939 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature