Ontology highlight
ABSTRACT:
SUBMITTER: Guma M
PROVIDER: S-EPMC2688966 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Guma Monica M Rius Jordi J Duong-Polk Karen X KX Haddad Gabriel G GG Lindsey James D JD Karin Michael M
Proceedings of the National Academy of Sciences of the United States of America 20090511 21
Many ocular pathologies, including retinopathy of prematurity (ROP), diabetic retinopathy, and age-related macular degeneration, result in vision loss because of aberrant neoangiogenesis. A common feature of these conditions is the presence of hypoxic areas and overexpression of the proangiogenic vascular endothelial growth factor (VEGF). The prevailing current treatment, laser ablation of the retina, is destructive and only partially effective. Preventive and less destructive therapies are much ...[more]