OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis.

ABSTRACT:

Background

The quantitative analysis of metabolic fluxes, i.e., in vivo activities of intracellular enzymes and pathways, provides key information on biological systems in systems biology and metabolic engineering. It is based on a comprehensive approach combining (i) tracer cultivation on 13C substrates, (ii) 13C labelling analysis by mass spectrometry and (iii) mathematical modelling for experimental design, data processing, flux calculation and statistics. Whereas the cultivation and the analytical part is fairly advanced, a lack of appropriate modelling software solutions for all modelling aspects in flux studies is limiting the application of metabolic flux analysis.

Results

We have developed OpenFLUX as a user friendly, yet flexible software application for small and l

SUBMITTER: Quek LE 

PROVIDER: S-EPMC2689189 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature