Comparative genomics of Toll-like receptor signalling in five species.

ABSTRACT:

Background

Over the last decade, several studies have identified quantitative trait loci (QTL) affecting variation of immune related traits in mammals. Recent studies in humans and mice suggest that part of this variation may be caused by polymorphisms in genes involved in Toll-like receptor (TLR) signalling. In this project, we used a comparative approach to investigate the importance of TLR-related genes in comparison with other immunologically relevant genes for resistance traits in five species by associating their genomic location with previously published immune-related QTL regions.

Results

We report the genomic localisation of TLR1-10 and ten associated signalling molecules in sheep and pig using in-silico and/or radiation hybrid (RH) mapping techniques and compare th

SUBMITTER: Jann OC 

PROVIDER: S-EPMC2689273 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature