Estimation of the optimal statistical quality control sampling time intervals using a residual risk measure.

ABSTRACT:

Background

An open problem in clinical chemistry is the estimation of the optimal sampling time intervals for the application of statistical quality control (QC) procedures that are based on the measurement of control materials. This is a probabilistic risk assessment problem that requires reliability analysis of the analytical system, and the estimation of the risk caused by the measurement error.

Methodology/principal findings

Assuming that the states of the analytical system are the reliability state, the maintenance state, the critical-failure modes and their combinations, we can define risk functions based on the mean time of the states, their measurement error and the medically acceptable measurement error. Consequently, a residual risk measure rr can be defined for ea

SUBMITTER: Hatjimihail AT 

PROVIDER: S-EPMC2689359 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature