Social stress-induced bladder dysfunction: potential role of corticotropin-releasing factor.

ABSTRACT: Psychological stress can impact on visceral function with pathological consequences, although the mechanisms underlying this are poorly understood. Here we demonstrate that social stress produces marked changes in bladder structure and function. Male rats were subjected to repeated (7 days) social defeat stress using the resident-intruder model. Measurement of the voiding pattern indicated that social stress produced urinary retention. Consistent with this, bladder size was increased in rats exposed to social stress. Moreover, this was negatively correlated to the latency to assume a subordinate posture, implying an association between passive behavior and bladder dysfunction. In vivo cystometry revealed distinct changes in urodynamic function in rats exposed to social stress, including in

SUBMITTER: Wood SK 

PROVIDER: S-EPMC2689833 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature