Costs and cost-effectiveness of four treatment regimens for latent tuberculosis infection.

ABSTRACT:

Rationale

Isoniazid given daily for 9 months is the standard treatment for latent tuberculosis infection (LTBI), but its effectiveness is limited by poor completion rates. Shorter course regimens and regimens using directly observed therapy result in improved adherence but have higher upfront costs.

Objectives

To evaluate the costs and cost-effectiveness of regimens for the treatment of LTBI.

Methods

We used a computerized Markov model to estimate total societal costs and benefits associated with four regimens for the treatment of LTBI: self-administered isoniazid daily for 9 months, directly observed isoniazid twice-weekly for 9 months, directly observed isoniazid plus rifapentine once weekly for 3 months, and self-administered rifampin daily for 4 months. In the bas

SUBMITTER: Holland DP 

PROVIDER: S-EPMC2689913 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature