Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.

ABSTRACT:

Background

Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis.

Methods and results

A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving a total of 4645 patients with myocardial infarction or CAD and 5177 controls. The mode of inheritance was determined. In addition, in 5 of the 7 studies, we genotyped 3 additional SNPs to assess a risk-associated haplotype (ACAC). Finally, a meta-analysis of the present data and previously published samples was conducted. A limited fine mapping of the locus was perform

SUBMITTER: Schunkert H 

PROVIDER: S-EPMC2689930 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature