Ontology highlight
ABSTRACT:
SUBMITTER: Yamane T
PROVIDER: S-EPMC2690003 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Yamane Toshiyuki T Hosen Naoki N Yamazaki Hidetoshi H Weissman Irving L IL
Proceedings of the National Academy of Sciences of the United States of America 20090519 22
The hematopoietic system of mice is established during the early to midgestational stage of development. However, the earliest lymphohematopoietic progenitors that appear during mouse development have been less well characterized compared with the hematopoietic stem cell compartment of fetal liver and bone marrow. We isolated the earliest lymphohematopoietic progenitors by using embryonic stem (ES) cell culture in vitro. Cells with the c-Kit(+)Lin(-) cell surface phenotype were present abundantl ...[more]