Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis.

ABSTRACT: During the development of neural circuitry, neurons of different kinds establish specific synaptic connections by selecting appropriate targets from large numbers of alternatives. The range of alternative targets is reduced by well organised patterns of growth, termination, and branching that deliver the terminals of appropriate pre- and postsynaptic partners to restricted volumes of the developing nervous system. We use the axons of embryonic Drosophila sensory neurons as a model system in which to study the way in which growing neurons are guided to terminate in specific volumes of the developing nervous system. The mediolateral positions of sensory arbors are controlled by the response of Robo receptors to a Slit gradient. Here we make a genetic analysis of factors regulating position i

SUBMITTER: Zlatic M 

PROVIDER: S-EPMC2690435 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature