H3 k36 methylation helps determine the timing of cdc45 association with replication origins.

ABSTRACT:

Background

Replication origins fire at different times during S-phase. Such timing is determined by the chromosomal context, which includes the activity of nearby genes, telomeric position effects and chromatin structure, such as the acetylation state of the surrounding chromatin. Activation of replication origins involves the conversion of a pre-replicative complex to a replicative complex. A pivotal step during this conversion is the binding of the replication factor Cdc45, which associates with replication origins at approximately their time of activation in a manner partially controlled by histone acetylation.

Methodology/principal findings

Here we identify histone H3 K36 methylation (H3 K36me) by Set2 as a novel regulator of the time of Cdc45 association with replicatio

SUBMITTER: Pryde F 

PROVIDER: S-EPMC2690658 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature