Variation in GIGYF2 is not associated with Parkinson disease.

ABSTRACT:

Objective

A recent study reported that mutations in a gene on chromosome 2q36-37, GIGYF2, result in Parkinson disease (PD). We have previously reported linkage to this chromosomal region in a sample of multiplex PD families, with the strongest evidence of linkage obtained using the subset of the sample having the strongest family history of disease and meeting the strictest diagnostic criteria. We have tested whether mutations in GIGYF2 may account for the previously observed linkage finding.

Methods

We sequenced the GIGYF2 coding region in 96 unrelated patients with PD used in our original study that contributed to the chromosome 2q36-37 linkage signal. Subsequently, we genotyped the entire sample of 566 multiplex PD kindreds as well as 1,447 controls to test whether varian

SUBMITTER: Nichols WC 

PROVIDER: S-EPMC2690967 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature