Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year.

ABSTRACT:

Background

Measurement of volumetric changes with MR might be a useful surrogate endpoint for clinical trials in frontotemporal lobar degeneration (FTLD). Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular volume (VV) in patients with FTLD.

Methods

Subjects with an FTLD cognitive syndrome were recruited from five centers using standard clinical diagnostic criteria for behavioral variant frontotemporal dementia (bvFTD), progressive nonfluent aphasia (PNFA), semantic dementia (SMD), and progressive logopenic aphasia. Structural brain imaging, using three-dimensional T1-weighted sequences at 1.5 teslas, and cognitive, behavioral, and functional assessments were perfo

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC2690986 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature