Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy.

ABSTRACT:

Objective

To investigate interhemispheric and intrahemispheric reorganization in patients with localization-related epilepsy.

Method

We studied 50 patients with a left hemispheric focus and 20 normal right-handed controls with a 3T echoplanar imaging blood oxygen level dependent functional MRI auditory-based word definition decision task. Data were analyzed using SPM 2. Using region of interest for Broca and Wernicke areas and an asymmetry index (AI), patients were categorized as left language (LL; AI > or = 0.20) or atypical language (AL; AI <0.20) for region. The point maxima activation for normal controls (p <0.05 corrected FDR) was identified in Broca and midtemporal regions and then used as a point of reference for individual point maxima identified at p < 0.001, uncorr

SUBMITTER: Rosenberger LR 

PROVIDER: S-EPMC2690987 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature