Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles.

ABSTRACT: Helicobacter pylori strains display remarkable genetic diversity, and the presence of strains bearing the toxigenic vacA s1 allele, a complete cag pathogenicity island (PAI), cagA alleles containing multiple EPIYA phosphorylation sites, and expressing the BabA adhesin correlates with development of gastroduodenal disease in adults. To better understand the genetic variability present among pediatric strains and its relationship to disease, we characterized H. pylori strains infecting 47 pediatric North American patients. Prevalence of mixed infection was assessed by random amplified polymorphic DNA analysis of multiple H. pylori clones from each patient. Microarray-based comparative genomic hybridization was used to examine the genomic content of the pediatric strains. The cagA and vacA al

SUBMITTER: Talarico S 

PROVIDER: S-EPMC2691067 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature