Systemic disease-induced salivary biomarker profiles in mouse models of melanoma and non-small cell lung cancer.

ABSTRACT:

Background

Saliva (oral fluids) is an emerging biofluid poised for detection of clinical diseases. Although the rationale for oral diseases applications (e.g. oral cancer) is intuitive, the rationale and relationship between systemic diseases and saliva biomarkers are unclear.

Methodology/principal findings

In this study, we used mouse models of melanoma and non-small cell lung cancer and compared the transcriptome biomarker profiles of tumor-bearing mice to those of control mice. Microarray analysis showed that salivary transcriptomes were significantly altered in tumor-bearing mice vs. controls. Significant overlapping among transcriptomes of mouse tumors, serum, salivary glands and saliva suggests that salivary biomarkers have multiple origins. Furthermore, we identified

SUBMITTER: Gao K 

PROVIDER: S-EPMC2691577 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature