Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas.

ABSTRACT: Nuclear receptors and coregulators are multifaceted players in normal metabolic and homeostatic processes in addition to a variety of disease states including cancer, inflammation, diabetes, obesity, and atherosclerosis. Over the past 7 yr, the Nuclear Receptor Signaling Atlas (NURSA) research consortium has worked toward establishing a discovery-driven platform designed to address key questions concerning the expression, organization, and function of these molecules in a variety of experimental model systems. By applying powerful technologies such as quantitative PCR, high-throughput mass spectrometry, and embryonic stem cell manipulation, we are pursuing these questions in a series of transcriptomics-, proteomics-, and metabolomics-based research projects and resources. The consortium's

SUBMITTER: McKenna NJ 

PROVIDER: S-EPMC2691684 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature