Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.

ABSTRACT: A major challenge to successful antiviral therapy is the emergence of drug-resistant viruses. Recent studies have developed several automated analyses of HIV sequence polymorphism based on calculations of selection pressure (K(a)/K(s)) to predict drug resistance mutations. Similar resistance analysis programs for HCV inhibitors are not currently available. Taking advantage of the recently available sequence data of patient HCV samples from a Phase II clinical study of protease inhibitor boceprevir, we calculated the selection pressure for all codons in the HCV protease region (amino acid 1-181) to identify potential resistance mutations. The correlation between mutations was also calculated to evaluate linkage between any two mutations. Using this approach, we identified previously known m

SUBMITTER: Qiu P 

PROVIDER: S-EPMC2691846 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature