Sequence variations within protein families are linearly related to structural variations.

ABSTRACT: It is commonly believed that similarities between the sequences of two proteins infer similarities between their structures. Sequence alignments reliably recognize pairs of protein of similar structures provided that the percentage sequence identity between their two sequences is sufficiently high. This distinction, however, is statistically less reliable when the percentage sequence identity is lower than 30% and little is known then about the detailed relationship between the two measures of similarity. Here, we investigate the inverse correlation between structural similarity and sequence similarity on 12 protein structure families. We define the structure similarity between two proteins as the cRMS distance between their structures. The sequence similarity for a pair of proteins is mea

SUBMITTER: Koehl P 

PROVIDER: S-EPMC2692051 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature