Daily changes in GT1-7 cell sensitivity to GnRH secretagogues that trigger ovulation.

ABSTRACT: Circadian rhythms in behavior and physiology are orchestrated by a master biological clock located in the suprachiasmatic nucleus (SCN). Circadian oscillations are a cellular property, with 'clock' genes and their protein products forming transcription-translation feedback loops that maintain 24-hour rhythmicity. Although the expression of clock genes is thought to be ubiquitous, the function of local, extra-SCN timing mechanisms remains elusive. We hypothesized that extra-SCN clock genes control local temporal sensitivity to upstream modulatory signals, allowing system-specific processes to be carried out during individual, optimal times of day. To test this possibility, we examined changes in the sensitivity of immortalized GnRH neurons, GT1-7 cells, to timed stimulation by two key neuro

SUBMITTER: Zhao S 

PROVIDER: S-EPMC2692455 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature