Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

ABSTRACT:

Background

Recurrent venous thromboembolism (VTE) is a common, complex disorder; however, genetic factors have been suggested to play a role in the disease development. We therefore conducted a multi-locus genetic study examining the potential associations of candidate gene variants in inflammation, thrombosis, coagulation, and lipid metabolism pathways, individually or interactively, with risk of recurrent VTE.

Methods

Using DNA samples collected at baseline in the Prevention of Recurrent Venous Thromboembolism trial (PREVENT), we genotyped 86 candidate genes polymorphisms among 43 individuals who subsequently developed recurrent VTE and among 396 individuals who remained free of recurrent event over a mean follow-up period of 2.1 years to prospectively determine whether th

SUBMITTER: Zee RY 

PROVIDER: S-EPMC2693946 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature