Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene).

ABSTRACT:

Objective

Few studies have examined the association between genetic variants of the estrogen receptor beta (ESR2) and obesity in postmenopausal women.

Methods

The relationship of three polymorphisms (rs1271572, rs1256049 and rs4986938) and their associated haplotypes in the ESR2 gene with obesity and overweight were evaluated in 561 apparently healthy women (median age 63 years) from the Women's Health Study. Most of the women were postmenopausal (99.1%). The associations between genotypes and haplotypes with obesity (BMI> or =30kg/m(2)) and overweight (BMI> or =25kg/m(2)) were evaluated by logistic regression, assuming an additive model.

Results

No association was observed for any of the three polymorphisms with BMI, overweight or obesity. In haplotype analyses, one

SUBMITTER: Goulart AC 

PROVIDER: S-EPMC2693958 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature