Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci.

ABSTRACT:

Objective

To identify putative genetic loci related to the risk of late-onset Alzheimer disease (LOAD).

Design

Linkage analysis and family-based and case-control association analyses from a genomewide scan using approximately 6000 single-nucleotide polymorphic markers at an average intermarker distance of 0.65 cM.

Setting

The National Institute on Aging Genetics Initiative for Late-Onset Alzheimer's Disease (NIA-LOAD) was created to expand the resources for studies to identify additional genes contributing to the risk for LOAD.

Participants

We investigated 1902 individuals from 328 families with LOAD and 236 unrelated control subjects.

Main outcome measures

Clinical diagnosis of LOAD.

Results

The strongest overall finding was at chromosome 19q13.3

SUBMITTER: Lee JH 

PROVIDER: S-EPMC2694670 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature