Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs.

ABSTRACT:

Background

Host protein-protein interaction networks are altered by invading virus proteins, which create new interactions, and modify or destroy others. The resulting network topology favors excessive amounts of virus production in a stressed host cell network. Short linear peptide motifs common to both virus and host provide the basis for host network modification.

Methods

We focused our host-pathogen study on the binding and competing interactions of HIV-1 and human proteins. We showed that peptide motifs conserved across 70% of HIV-1 subtype B and C samples occurred in similar positions on HIV-1 proteins, and we documented protein domains that interact with these conserved motifs. We predicted which human proteins may be targeted by HIV-1 by taking pairs of human protein

SUBMITTER: Evans P 

PROVIDER: S-EPMC2694829 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature