Association analysis of TNFRSF1B polymorphisms with type 2 diabetes and its related traits in North India.

ABSTRACT: Inflammation plays a crucial role in the pathogenesis of type 2 diabetes and various lines of evidences suggest an important contribution of type 2 receptor for TNFalpha (TNFR2), a mediator of inflammatory responses. Though genetic association of TNFRSF1B (encoding TNFR2) polymorphisms have been investigated in various studies, their involvement is not clear because of inconsistent findings. Because of high susceptibility of Indian population to type 2 diabetes and its complications, we evaluated the association of TNFRSF1B polymorphisms-rs1061622 (M196R; exon6) and rs3397 (3'UTR) and (CA)( n ) repeat (intron 4) in 1,852 subjects including 1,040 cases and 812 controls with type 2 diabetes and its associated peripheral neuropathy and hypertension in North Indians of Indo-European ethnicity.

SUBMITTER: Tabassum R 

PROVIDER: S-EPMC2694862 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature