Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.

ABSTRACT:

Background

Recent studies have identified several single nucleotide polymorphisms (SNPs) in the population that are associated with variations in the risks of many different diseases including cancers such as breast, prostate and colorectal. For ovarian cancer, the known highly penetrant susceptibility genes (BRCA1 and BRCA2) are probably responsible for only 40% of the excess familial ovarian cancer risks, suggesting that other susceptibility genes of lower penetrance exist.

Methods

We have taken a candidate approach to identifying moderate risk susceptibility alleles for ovarian cancer. To date, we have genotyped 340 SNPs from 94 candidate genes or regions, in up to 1,491 invasive epithelial ovarian cancer cases and 3,145 unaffected controls from three different population

SUBMITTER: Quaye L 

PROVIDER: S-EPMC2695002 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature