Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations.

ABSTRACT:

Background

The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.

Methods

Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.

Results

In both populations genotype frequenci

SUBMITTER: Karakas M 

PROVIDER: S-EPMC2695426 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature