Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

ABSTRACT:

Rationale

Association studies have implicated many genes in asthma pathogenesis, with replicated associations between single-nucleotide polymorphisms (SNPs) and asthma reported for more than 30 genes. Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma.

Objectives

To use available genome-wide genotypic data to assess the reproducibility of previously reported associations with asthma and to evaluate the contribution of additional common genetic variation surrounding these loci to asthma susceptibility.

Methods

Illumina Human Hap 550Kv3 BeadChip (Illumina, San Diego, CA) SNP arrays were genotyped in 422 nuc

SUBMITTER: Rogers AJ 

PROVIDER: S-EPMC2695495 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature