Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma.

ABSTRACT:

Aim

To look at a comprehensive picture of etiology-dependent gene abnormalities in hepatocellular carcinoma in Western Europe.

Methods

With a liver-oriented microarray, transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism, 12; hepatitis C, 10) and 5 controls. Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set (12 + 10) and a test set (6 + 7).

Results

A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism) or -2 (hepatitis C) and ontology indicated a predominant inflammatory response (al

SUBMITTER: Derambure C 

PROVIDER: S-EPMC2695915 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature