Molecular determinants of juvenile hormone action as revealed by 3D QSAR analysis in Drosophila.

ABSTRACT:

Background

Postembryonic development, including metamorphosis, of many animals is under control of hormones. In Drosophila and other insects these developmental transitions are regulated by the coordinate action of two principal hormones, the steroid ecdysone and the sesquiterpenoid juvenile hormone (JH). While the mode of ecdysone action is relatively well understood, the molecular mode of JH action remains elusive.

Methodology/principal findings

To gain more insights into the molecular mechanism of JH action, we have tested the biological activity of 86 structurally diverse JH agonists in Drosophila melanogaster. The results were evaluated using 3D QSAR analyses involving CoMFA and CoMSIA procedures. Using this approach we have generated both computer-aided and species-spe

SUBMITTER: Liszekova D 

PROVIDER: S-EPMC2696086 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature